Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC016
Test administered by neuromedic@manusdevices.net
Test date and time 2022-06-17 12:13
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250 mg 3x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 30 individuals with a value less than 0.63 were subsequently diagnosed with PD. That is, 71.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.63 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 36, 'TN': 26, 'TP': 6, 'FP': 4}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 31, 'TN': 26, 'TP': 11, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 35, 'TN': 29, 'TP': 7, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 15, 'TN': 9, 'TP': 27, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 17.44
timePerCircleCoV 0.210496
timePerCircleSlope -0.0549903
meanError 1.42107
tremorFreq 5.76172
tremorRelPower 24.9204
tremorGyroAmpMean 0.0126281
tremorGyroAmpSlope -0.000832006
tremorGyroAmpCoV 0.448469
tremorCoordAmpMean 0.0286929
tremorCoordAmpSlope -0.000380581
tremorCoordAmpCoV 0.365632
tremorAccAmpMean 0.0871622
tremorAccAmpSlope -0.000166196
tremorAccAmpCoV 0.0451107
tremorPcRelVar 0.674478
tremorPcX 0.541988
tremorPcY -0.840386

Circle Segment 1

Duration 19.2 s, Accuracy Estimate 1.556 (lower is better)

Circle Segment 2

Duration 26.2 s, Accuracy Estimate 1.522 (lower is better)

Circle Segment 3

Duration 18.28 s, Accuracy Estimate 0.966 (lower is better)

Circle Segment 4

Duration 16.56 s, Accuracy Estimate 1.086 (lower is better)

Circle Segment 5

Duration 19.08 s, Accuracy Estimate 1.356 (lower is better)

Circle Segment 6

Duration 17.12 s, Accuracy Estimate 1.256 (lower is better)

Circle Segment 7

Duration 15.56 s, Accuracy Estimate 1.162 (lower is better)

Circle Segment 8

Duration 14.64 s, Accuracy Estimate 1.193 (lower is better)

Circle Segment 9

Duration 14.36 s, Accuracy Estimate 1.672 (lower is better)

Circle Segment 10

Duration 13.4 s, Accuracy Estimate 2.443 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 40.4
timePerSpiralCoV 0.113063
timePerSpiralSlope 0.0192139
meanError 1.7374
tremorFreq 5.66406
tremorRelPower 24.3715
tremorGyroAmpMean 0.0136317
tremorGyroAmpSlope 0.000206491
tremorGyroAmpCoV 0.432778
tremorCoordAmpMean 0.0323829
tremorCoordAmpSlope -0.000299531
tremorCoordAmpCoV 0.288806
tremorAccAmpMean 0.0799643
tremorAccAmpSlope -2.97013e-05
tremorAccAmpCoV 0.0457905
tremorPcRelVar 0.616421
tremorPcX 0.414611
tremorPcY -0.909999

Spiral Segment 1

Duration 37.32 s, Accuracy Estimate 1.872 (lower is better)

Spiral Segment 2

Duration 41.4 s, Accuracy Estimate 1.71 (lower is better)

Spiral Segment 3

Duration 40.52 s, Accuracy Estimate 1.997 (lower is better)

Spiral Segment 4

Duration 35.2 s, Accuracy Estimate 1.632 (lower is better)

Spiral Segment 5

Duration 39.88 s, Accuracy Estimate 1.73 (lower is better)

Spiral Segment 6

Duration 35.2 s, Accuracy Estimate 1.606 (lower is better)

Spiral Segment 7

Duration 38.48 s, Accuracy Estimate 1.814 (lower is better)

Spiral Segment 8

Duration 42.76 s, Accuracy Estimate 1.518 (lower is better)

Spiral Segment 9

Duration 50.88 s, Accuracy Estimate 1.679 (lower is better)

Spiral Segment 10

Duration 42.36 s, Accuracy Estimate 1.816 (lower is better)

Elel

eDurationMean 0.705736
eDurationStd 0.233154
eDurationStdnorm 0.33037
eDurationMedian 0.65502
eDurationQuartdelta 0.220007
eDurationQuartdeltanorm 0.335878
eDurationKurt 6.16144
eDurationTrenddiff -0.230007
eDurationTrendratio 0.707006
eWidthMean 5.89327
eWidthStd 1.77951
eWidthStdnorm 0.301956
eWidthMedian 5.85
eWidthQuartdelta 2.36944
eWidthQuartdeltanorm 0.405032
eWidthKurt 2.4664
eWidthTrenddiff 0.117
eWidthTrendratio 1.02041
eHeightMean 11.8895
eHeightStd 4.49885
eHeightStdnorm 0.378389
eHeightMedian 12.2431
eHeightQuartdelta 5.47447
eHeightQuartdeltanorm 0.447149
eHeightKurt 2.72832
eHeightTrenddiff 0.936
eHeightTrendratio 1.07843
eAspectMean 0.600806
eAspectStd 0.424943
eAspectStdnorm 0.707289
eAspectMedian 0.513906
eAspectQuartdelta 0.268161
eAspectQuartdeltanorm 0.521809
eAspectKurt 12.0223
eAspectTrenddiff -0.0409626
eAspectTrendratio 0.921147
eSlantMean -0.181351
eSlantStd 0.212564
eSlantStdnorm -1.17211
eSlantMedian -0.1413
eSlantQuartdelta 0.261733
eSlantQuartdeltanorm -1.85232
eSlantKurt 3.72271
eSlantTrenddiff 0.0690097
eRtopMean 0.612219
eRtopStd 0.155303
eRtopStdnorm 0.253673
eRtopMedian 0.641026
eRtopQuartdelta 0.216412
eRtopQuartdeltanorm 0.337603
eRtopKurt 3.37613
eRtopTrenddiff -0.0197251
eRbotMean 0.947234
eRbotStd 0.341207
eRbotStdnorm 0.360214
eRbotMedian 0.944879
eRbotQuartdelta 0.407947
eRbotQuartdeltanorm 0.431746
eRbotKurt 3.69357
eRbotTrenddiff -0.226073
eRrightMean 0.694826
eRrightStd 0.240483
eRrightStdnorm 0.346105
eRrightMedian 0.751022
eRrightQuartdelta 0.323883
eRrightQuartdeltanorm 0.431256
eRrightKurt 3.73898
eRrightTrenddiff 0.0620999
eRleftMean 0.53688
eRleftStd 0.165514
eRleftStdnorm 0.308288
eRleftMedian 0.564364
eRleftQuartdelta 0.225081
eRleftQuartdeltanorm 0.398823
eRleftKurt 3.73302
eRleftTrenddiff -0.113485
lDurationMean 0.869764
lDurationStd 0.335986
lDurationStdnorm 0.386296
lDurationMedian 0.732523
lDurationQuartdelta 0.415013
lDurationQuartdeltanorm 0.566553
lDurationKurt 4.58286
lDurationTrenddiff -0.410013
lDurationTrendratio 0.611374
lWidthMean 11.3766
lWidthStd 4.34044
lWidthStdnorm 0.381523
lWidthMedian 11.2907
lWidthQuartdelta 7.34853
lWidthQuartdeltanorm 0.65085
lWidthKurt 1.97625
lWidthTrenddiff 6.201
lWidthTrendratio 1.74648
lHeightMean 32.407
lHeightStd 6.12981
lHeightStdnorm 0.189151
lHeightMedian 32.5845
lHeightQuartdelta 9.63578
lHeightQuartdeltanorm 0.295717
lHeightKurt 2.38047
lHeightTrenddiff 7.08494
lHeightTrendratio 1.24472
lAspectMean 0.344439
lAspectStd 0.0992647
lAspectStdnorm 0.288192
lAspectMedian 0.353461
lAspectQuartdelta 0.161897
lAspectQuartdeltanorm 0.458033
lAspectKurt 2.23862
lAspectTrenddiff 0.115648
lAspectTrendratio 1.41275
lSlantMean 0.058748
lSlantStd 0.119182
lSlantStdnorm 2.0287
lSlantMedian 0.0695439
lSlantQuartdelta 0.157545
lSlantQuartdeltanorm 2.2654
lSlantKurt 3.19685
lSlantTrenddiff 0.0868758
lRtopMean 0.73462
lRtopStd 0.165544
lRtopStdnorm 0.225346
lRtopMedian 0.767941
lRtopQuartdelta 0.128669
lRtopQuartdeltanorm 0.167551
lRtopKurt 5.68271
lRtopTrenddiff 0.0969427
lRbotMean 0.651266
lRbotStd 0.337795
lRbotStdnorm 0.518675
lRbotMedian 0.587287
lRbotQuartdelta 0.252041
lRbotQuartdeltanorm 0.429162
lRbotKurt 9.34816
lRbotTrenddiff -0.213069
lRrightMean 0.856817
lRrightStd 0.110836
lRrightStdnorm 0.129357
lRrightMedian 0.880625
lRrightQuartdelta 0.0937495
lRrightQuartdeltanorm 0.106458
lRrightKurt 7.82891
lRrightTrenddiff 0.0677668
lRleftMean 0.439855
lRleftStd 0.169685
lRleftStdnorm 0.385775
lRleftMedian 0.413484
lRleftQuartdelta 0.290698
lRleftQuartdeltanorm 0.703046
lRleftKurt 2.9469
lRleftTrenddiff -0.11238

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.974184
sumTouchScores 14.6128
meanMovementTime 1.16179
numTouches 15
undershootPercentage 0
overshootPercentage 6.66667

FITTS Long Modified

meanTouchScore 1
sumTouchScores 14
meanMovementTime 1.38231
numTouches 14
undershootPercentage 0
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 30.376
timePerZigzagCoV 0.228986
timePerZigzagSlope -0.129576
meanError 1.89761
tremorFreq 5.66406
tremorRelPower 24.509
tremorGyroAmpMean 0.0191964
tremorGyroAmpSlope -0.000523506
tremorGyroAmpCoV 0.31692
tremorCoordAmpMean 0.0403804
tremorCoordAmpSlope 0.0018965
tremorCoordAmpCoV 0.321288
tremorAccAmpMean 0.0826681
tremorAccAmpSlope 0.00036639
tremorAccAmpCoV 0.0724447
tremorPcRelVar 0.722504
tremorPcX 0.00318962
tremorPcY -0.999995

ZigZag Segment 1

Duration 42.0 s, Accuracy Estimate 2.146 (lower is better)

ZigZag Segment 2

Duration 30.04 s, Accuracy Estimate 1.661 (lower is better)

ZigZag Segment 3

Duration 29.84 s, Accuracy Estimate 1.61 (lower is better)

ZigZag Segment 4

Duration 25.32 s, Accuracy Estimate 1.792 (lower is better)

ZigZag Segment 5

Duration 24.68 s, Accuracy Estimate 2.279 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 25.58
timePerZigzagCoV 0.315754
timePerZigzagSlope -0.210477
zigzagHeightMean 67.1722
zigzagHeightCoV 0.0806072
zigzagHeightSlope 0.0395338
meanError 0.0648836
tremorFreq 5.56641
tremorRelPower 28.0484
tremorGyroAmpMean 0.0419667
tremorGyroAmpSlope 0.00482966
tremorGyroAmpCoV 0.516913
tremorCoordAmpMean 0.0611343
tremorCoordAmpSlope 0.00317729
tremorCoordAmpCoV 0.486879
tremorAccAmpMean 0.06387
tremorAccAmpSlope 0.0013697
tremorAccAmpCoV 0.295049
tremorPcRelVar 0.786011
tremorPcX -0.348956
tremorPcY -0.937139

ZigZag Offset Segment 1

Duration 34.32 s, Accuracy Estimate 0.07 (lower is better)

ZigZag Offset Segment 2

Duration 24.52 s, Accuracy Estimate 0.061 (lower is better)

ZigZag Offset Segment 3

Duration 28.4 s, Accuracy Estimate 0.078 (lower is better)

ZigZag Offset Segment 4

Duration 15.08 s, Accuracy Estimate 0.05 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.32}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.63}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7907405822712936}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8980836873835065}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8228163993316099}